Strain-dependent profile of misfolded prion protein aggregates
نویسندگان
چکیده
منابع مشابه
Strain-dependent profile of misfolded prion protein aggregates
Prions are composed of the misfolded prion protein (PrP(Sc)) organized in a variety of aggregates. An important question in the prion field has been to determine the identity of functional PrP(Sc) aggregates. In this study, we used equilibrium sedimentation in sucrose density gradients to separate PrP(Sc) aggregates from three hamster prion strains (Hyper, Drowsy, SSLOW) subjected to minimal ma...
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List of abbreviations Alzheimer’s Disease, AD; Amyloid Precursor Protein, APP; Beta-Amyloid, Aβ; Bovine Spongiform Encephalopathy, BSE; Creutzfeldt-Jakob Disease, CJD; Central Nervous System, CNS; Immunofluorescence, IF; Immunoprecipitation, IP; Enzyme Linked Immunosorbent Assay, ELISA; Huntingtin, Htt; Huntington’s Disease, HD; Immunohistochemistry, IHC; Luminescent Conjugated Oligothiophenes,...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep20526